MIR6753

Summary

MIR6753 (microRNA 6753, HGNC:50255) is a microRNA gene on chromosome 11q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465451 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50255
Approved symbol	MIR6753
Name	microRNA 6753
Location	11q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6753
Ensembl gene	ENSG00000275022
Ensembl biotype	miRNA
Entrez	102465451
RNAcentral	URS000075CB3A — miRNA, 164 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617169

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617169 — 1 exons

Exon	Start	End
ENSE00003742564	68044794	68044957

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 92.25.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	92.25	gold quality
granulocyte	CL:0000094	90.84	gold quality
body of pancreas	UBERON:0001150	88.84	gold quality
pancreas	UBERON:0001264	87.68	gold quality
spleen	UBERON:0002106	84.98	gold quality
upper lobe of left lung	UBERON:0008952	81.39	gold quality
left adrenal gland cortex	UBERON:0035825	80.82	gold quality
leukocyte	CL:0000738	80.54	gold quality
right adrenal gland	UBERON:0001233	80.37	gold quality
monocyte	CL:0000576	80.28	gold quality
ectocervix	UBERON:0012249	80.08	gold quality
right coronary artery	UBERON:0001625	79.68	gold quality
endocervix	UBERON:0000458	79.64	gold quality
left adrenal gland	UBERON:0001234	79.31	gold quality
left uterine tube	UBERON:0001303	79.23	gold quality
right adrenal gland cortex	UBERON:0035827	79.08	gold quality
right uterine tube	UBERON:0001302	78.90	gold quality
lung	UBERON:0002048	78.90	gold quality
adrenal gland	UBERON:0002369	78.79	gold quality
right lung	UBERON:0002167	78.66	gold quality
prostate gland	UBERON:0002367	78.53	gold quality
adrenal tissue	UBERON:0018303	77.67	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.54	gold quality
vermiform appendix	UBERON:0001154	77.38	gold quality
descending thoracic aorta	UBERON:0002345	77.25	gold quality
small intestine	UBERON:0002108	77.18	gold quality
minor salivary gland	UBERON:0001830	77.02	gold quality
saliva-secreting gland	UBERON:0001044	77.01	gold quality
prefrontal cortex	UBERON:0000451	77.00	gold quality
right ovary	UBERON:0002118	76.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.