MIR6754

Summary

MIR6754 (microRNA 6754, HGNC:50203) is a microRNA gene on chromosome 11q13.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466728 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50203
Approved symbol	MIR6754
Name	microRNA 6754
Location	11q13.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6754
Ensembl gene	ENSG00000278349
Ensembl biotype	miRNA
Entrez	102466728
RNAcentral	URS000075BCA9 — miRNA, 66 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621121

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621121 — 1 exons

Exon	Start	End
ENSE00003739705	71473503	71473568

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 80.19.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.19	gold quality
adrenal tissue	UBERON:0018303	78.72	gold quality
monocyte	CL:0000576	78.02	gold quality
right ovary	UBERON:0002118	73.45	gold quality
gastrocnemius	UBERON:0001388	73.35	gold quality
heart	UBERON:0000948	73.30	gold quality
liver	UBERON:0002107	73.24	gold quality
heart left ventricle	UBERON:0002084	72.91	gold quality
anterior cingulate cortex	UBERON:0009835	71.98	gold quality
endometrium	UBERON:0001295	71.07	gold quality
Ammon’s horn	UBERON:0001954	70.79	gold quality
hypothalamus	UBERON:0001898	70.65	gold quality
right atrium auricular region	UBERON:0006631	70.37	gold quality
left adrenal gland cortex	UBERON:0035825	69.76	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.61	gold quality
tibial artery	UBERON:0007610	69.25	gold quality
fundus of stomach	UBERON:0001160	69.24	gold quality
body of pancreas	UBERON:0001150	69.22	gold quality
stomach	UBERON:0000945	69.10	gold quality
body of stomach	UBERON:0001161	69.10	gold quality
adult mammalian kidney	UBERON:0000082	68.60	gold quality
left adrenal gland	UBERON:0001234	68.56	gold quality
urinary bladder	UBERON:0001255	67.81	gold quality
colon	UBERON:0001155	66.76	gold quality
transverse colon	UBERON:0001157	66.54	gold quality
ascending aorta	UBERON:0001496	66.40	gold quality
putamen	UBERON:0001874	66.37	gold quality
skin of leg	UBERON:0001511	66.33	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.28	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• it was demonstrated that inhibition of miR67545p reversed the effects of LINC00978 knockdown on nonsmall cell lung cancer (NSCLC)cell proliferation, migration, invasion and apoptosis. In conclusion, results of the present study demonstrated that LINC00978 exerts an oncogenic role in nonsmall cell lung cancer (NSCLC)by inhibiting miR67545p expression (PMID:30221669)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.