MIR6756

Summary

MIR6756 (microRNA 6756, HGNC:49974) is a microRNA gene on chromosome 11q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465453 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49974
Approved symbol	MIR6756
Name	microRNA 6756
Location	11q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6756
Ensembl gene	ENSG00000284148
Ensembl biotype	miRNA
Entrez	102465453
RNAcentral	URS000075BA23 — ncRNA, 63 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616240

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616240 — 1 exons

Exon	Start	End
ENSE00001513247	119312950	119313012

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 70.85.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	70.85	gold quality
heart left ventricle	UBERON:0002084	68.64	gold quality
right atrium auricular region	UBERON:0006631	65.25	gold quality
amygdala	UBERON:0001876	62.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.48	gold quality
nucleus accumbens	UBERON:0001882	61.12	gold quality
caudate nucleus	UBERON:0001873	60.59	gold quality
pituitary gland	UBERON:0000007	59.87	gold quality
skin of leg	UBERON:0001511	59.86	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.12	gold quality
transverse colon	UBERON:0001157	58.36	gold quality
right frontal lobe	UBERON:0002810	56.48	gold quality
esophagus mucosa	UBERON:0002469	56.02	gold quality
upper lobe of left lung	UBERON:0008952	55.18	gold quality
skin of abdomen	UBERON:0001416	54.52	gold quality
Ammon’s horn	UBERON:0001954	52.48	gold quality
cerebellar hemisphere	UBERON:0002245	52.06	gold quality
hypothalamus	UBERON:0001898	50.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• hsa_circ_0000417 downregulation suppresses androgen receptor expression and apoptotic signals in human foreskin fibroblasts via sponging miR-6756-5p. (PMID:37389702)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.