MIR6757

Summary

MIR6757 (microRNA 6757, HGNC:50160) is a microRNA gene on chromosome 12q13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466193 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50160
Approved symbol	MIR6757
Name	microRNA 6757
Location	12q13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6757
Ensembl gene	ENSG00000278108
Ensembl biotype	miRNA
Entrez	102466193
RNAcentral	URS000075C49A — miRNA, 69 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612099

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612099 — 1 exons

Exon	Start	End
ENSE00003730595	53056944	53057012

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 94.50.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	94.50	gold quality
tibial nerve	UBERON:0001323	93.11	gold quality
subcutaneous adipose tissue	UBERON:0002190	93.10	gold quality
sural nerve	UBERON:0015488	93.02	gold quality
skeletal muscle tissue	UBERON:0001134	92.12	gold quality
right adrenal gland	UBERON:0001233	91.72	gold quality
adipose tissue	UBERON:0001013	91.47	gold quality
right ovary	UBERON:0002118	90.51	gold quality
right adrenal gland cortex	UBERON:0035827	90.32	gold quality
heart left ventricle	UBERON:0002084	90.31	gold quality
myometrium	UBERON:0001296	90.22	gold quality
right atrium auricular region	UBERON:0006631	90.20	gold quality
left adrenal gland cortex	UBERON:0035825	89.90	gold quality
heart	UBERON:0000948	89.74	gold quality
mucosa of stomach	UBERON:0001199	89.68	gold quality
endocervix	UBERON:0000458	89.65	gold quality
omental fat pad	UBERON:0010414	89.55	gold quality
left ovary	UBERON:0002119	89.32	gold quality
body of uterus	UBERON:0009853	89.17	gold quality
ovary	UBERON:0000992	89.03	gold quality
metanephros cortex	UBERON:0010533	88.98	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	88.95	gold quality
vermiform appendix	UBERON:0001154	88.93	gold quality
left adrenal gland	UBERON:0001234	88.90	gold quality
thoracic mammary gland	UBERON:0005200	88.87	gold quality
fundus of stomach	UBERON:0001160	88.86	gold quality
adrenal gland	UBERON:0002369	88.86	gold quality
lower esophagus muscularis layer	UBERON:0035833	88.54	gold quality
right lobe of liver	UBERON:0001114	88.51	gold quality
lower esophagus	UBERON:0013473	88.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC02086 promotes cell viability and inhibits cell apoptosis in breast cancer by sponging miR-6757-5p and up-regulating EPHA2. (PMID:38008720)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.