MIR6759

Summary

MIR6759 (microRNA 6759, HGNC:50063) is a microRNA gene on chromosome 12q14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466729 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50063
Approved symbol	MIR6759
Name	microRNA 6759
Location	12q14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6759
Ensembl gene	ENSG00000283621
Ensembl biotype	miRNA
Entrez	102466729
RNAcentral	URS000075DB36 — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000638110

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638110 — 1 exons

Exon	Start	End
ENSE00003799254	57748618	57748682

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 68.94.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colon	UBERON:0001155	68.94	gold quality
right atrium auricular region	UBERON:0006631	67.91	gold quality
gastrocnemius	UBERON:0001388	67.62	gold quality
heart left ventricle	UBERON:0002084	66.02	gold quality
adult mammalian kidney	UBERON:0000082	65.44	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	58.97	gold quality
body of pancreas	UBERON:0001150	57.62	gold quality
body of stomach	UBERON:0001161	56.04	gold quality
minor salivary gland	UBERON:0001830	50.46	gold quality
caudate nucleus	UBERON:0001873	45.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	43.98	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Lnc-MCEI mediated the chemosensitivity of esophageal squamous cell carcinoma via miR-6759-5p to competitively regulate IGF2. (PMID:33061807)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.