MIR676

Summary

MIR676 (microRNA 676, HGNC:38880) is a microRNA gene on chromosome Xq13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500887 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38880
Approved symbol	MIR676
Name	microRNA 676
Location	Xq13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-676
Ensembl gene	ENSG00000211991
Ensembl biotype	miRNA
Entrez	100500887
RNAcentral	URS000075F10F — miRNA, 67 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390702

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390702 — 1 exons

Exon	Start	End
ENSE00001508379	70022857	70022923

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 77.86.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.86	gold quality
kidney	UBERON:0002113	74.64	gold quality
endometrium	UBERON:0001295	73.09	gold quality
heart left ventricle	UBERON:0002084	72.72	gold quality
heart	UBERON:0000948	71.61	gold quality
gastrocnemius	UBERON:0001388	71.60	gold quality
esophagus mucosa	UBERON:0002469	71.10	gold quality
body of pancreas	UBERON:0001150	70.62	gold quality
stomach	UBERON:0000945	70.61	gold quality
ascending aorta	UBERON:0001496	69.28	gold quality
thoracic aorta	UBERON:0001515	69.23	gold quality
right atrium auricular region	UBERON:0006631	69.03	gold quality
body of stomach	UBERON:0001161	68.51	gold quality
caudate nucleus	UBERON:0001873	68.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.01	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.84	gold quality
lung	UBERON:0002048	67.61	gold quality
tibial artery	UBERON:0007610	67.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.22	gold quality
right adrenal gland cortex	UBERON:0035827	66.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.15	gold quality
skin of abdomen	UBERON:0001416	65.06	gold quality
vagina	UBERON:0000996	65.03	gold quality
left ovary	UBERON:0002119	65.00	gold quality
intestine	UBERON:0000160	64.82	gold quality
ovary	UBERON:0000992	64.81	gold quality
left adrenal gland	UBERON:0001234	64.40	gold quality
left adrenal gland cortex	UBERON:0035825	64.38	gold quality
omental fat pad	UBERON:0010414	64.24	gold quality
tibial nerve	UBERON:0001323	64.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Mir676	ENSRNOG00000061112

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.