MIR6760

Summary

MIR6760 (microRNA 6760, HGNC:49955) is a microRNA gene on chromosome 12q24.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465455 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49955
Approved symbol	MIR6760
Name	microRNA 6760
Location	12q24.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6760
Ensembl gene	ENSG00000273700
Ensembl biotype	miRNA
Entrez	102465455
RNAcentral	URS000075C691 — ncRNA, 68 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617342

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617342 — 1 exons

Exon	Start	End
ENSE00003721149	111304142	111304209

Expression profiles

Bgee: expression breadth broad, 27 present calls, max score 73.57.

Top tissues by expression

27 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	73.57	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.56	gold quality
right lobe of thyroid gland	UBERON:0001119	70.95	gold quality
right lobe of liver	UBERON:0001114	70.81	gold quality
substantia nigra	UBERON:0002038	68.23	gold quality
transverse colon	UBERON:0001157	67.27	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.38	gold quality
omental fat pad	UBERON:0010414	65.99	gold quality
anterior cingulate cortex	UBERON:0009835	65.70	gold quality
prostate gland	UBERON:0002367	65.31	gold quality
left adrenal gland	UBERON:0001234	65.03	gold quality
multicellular organism	UBERON:0000468	64.72	gold quality
Ammon’s horn	UBERON:0001954	64.59	gold quality
brain	UBERON:0000955	64.17	gold quality
pituitary gland	UBERON:0000007	64.07	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.97	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.97	gold quality
nucleus accumbens	UBERON:0001882	63.91	gold quality
right frontal lobe	UBERON:0002810	63.82	gold quality
putamen	UBERON:0001874	63.81	gold quality
hypothalamus	UBERON:0001898	63.34	gold quality
thyroid gland	UBERON:0002046	62.97	gold quality
caudate nucleus	UBERON:0001873	62.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.44	gold quality
left lobe of thyroid gland	UBERON:0001120	59.05	gold quality
minor salivary gland	UBERON:0001830	57.35	gold quality
left testis	UBERON:0004533	38.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Hsa_circ_0076931 suppresses malignant biological properties, down-regulates miR-6760-3p through direct binding, and up-regulates CCBE1 in glioma. (PMID:34931668)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.