MIR6761

Summary

MIR6761 (microRNA 6761, HGNC:49949) is a microRNA gene on chromosome 12q24.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465456 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49949
Approved symbol	MIR6761
Name	microRNA 6761
Location	12q24.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6761
Ensembl gene	ENSG00000274697
Ensembl biotype	miRNA
Entrez	102465456
RNAcentral	URS000075A724 — ncRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617899

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617899 — 1 exons

Exon	Start	End
ENSE00003741377	111799834	111799905

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 77.57.

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	77.57	gold quality
adrenal tissue	UBERON:0018303	77.12	gold quality
liver	UBERON:0002107	75.75	gold quality
right lobe of liver	UBERON:0001114	75.09	gold quality
blood	UBERON:0000178	73.63	gold quality
fundus of stomach	UBERON:0001160	73.35	gold quality
muscle of leg	UBERON:0001383	72.86	gold quality
calcaneal tendon	UBERON:0003701	72.54	gold quality
right adrenal gland cortex	UBERON:0035827	72.10	gold quality
gastrocnemius	UBERON:0001388	72.03	gold quality
endometrium	UBERON:0001295	71.96	gold quality
stomach	UBERON:0000945	71.21	gold quality
adult mammalian kidney	UBERON:0000082	71.02	gold quality
islet of Langerhans	UBERON:0000006	70.56	gold quality
body of stomach	UBERON:0001161	69.94	gold quality
heart left ventricle	UBERON:0002084	69.82	gold quality
substantia nigra	UBERON:0002038	69.66	gold quality
body of pancreas	UBERON:0001150	69.11	gold quality
rectum	UBERON:0001052	68.67	gold quality
tibial artery	UBERON:0007610	68.67	gold quality
popliteal artery	UBERON:0002250	68.60	gold quality
heart	UBERON:0000948	68.29	gold quality
right adrenal gland	UBERON:0001233	68.23	gold quality
lung	UBERON:0002048	68.04	gold quality
right atrium auricular region	UBERON:0006631	67.83	gold quality
upper lobe of left lung	UBERON:0008952	67.70	gold quality
myometrium	UBERON:0001296	67.67	gold quality
transverse colon	UBERON:0001157	67.50	gold quality
colon	UBERON:0001155	67.10	gold quality
gall bladder	UBERON:0002110	67.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.