MIR6762

Summary

MIR6762 (microRNA 6762, HGNC:50168) is a microRNA gene on chromosome 12q24.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465457 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50168
Approved symbol	MIR6762
Name	microRNA 6762
Location	12q24.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6762
Ensembl gene	ENSG00000274822
Ensembl biotype	miRNA
Entrez	102465457
RNAcentral	URS000075B2A2 — ncRNA, 86 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613340

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613340 — 1 exons

Exon	Start	End
ENSE00003730306	113291523	113291608

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 80.15.

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.15	gold quality
lymph node	UBERON:0000029	78.24	gold quality
adrenal tissue	UBERON:0018303	76.73	gold quality
monocyte	CL:0000576	75.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.86	gold quality
muscle of leg	UBERON:0001383	74.05	gold quality
blood	UBERON:0000178	73.33	gold quality
gastrocnemius	UBERON:0001388	73.27	gold quality
urinary bladder	UBERON:0001255	72.31	gold quality
ectocervix	UBERON:0012249	72.28	gold quality
left adrenal gland cortex	UBERON:0035825	72.04	gold quality
heart left ventricle	UBERON:0002084	71.92	gold quality
calcaneal tendon	UBERON:0003701	71.60	gold quality
islet of Langerhans	UBERON:0000006	71.53	gold quality
heart	UBERON:0000948	70.82	gold quality
left adrenal gland	UBERON:0001234	70.72	gold quality
right atrium auricular region	UBERON:0006631	70.60	gold quality
right lung	UBERON:0002167	70.51	gold quality
placenta	UBERON:0001987	70.43	gold quality
right adrenal gland	UBERON:0001233	70.33	gold quality
ascending aorta	UBERON:0001496	70.29	gold quality
thoracic aorta	UBERON:0001515	70.08	gold quality
body of stomach	UBERON:0001161	69.87	gold quality
tibial artery	UBERON:0007610	69.85	gold quality
popliteal artery	UBERON:0002250	69.82	gold quality
body of pancreas	UBERON:0001150	69.66	gold quality
endometrium	UBERON:0001295	69.24	gold quality
right lobe of liver	UBERON:0001114	69.12	gold quality
stomach	UBERON:0000945	68.70	gold quality
metanephros cortex	UBERON:0010533	68.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.