MIR6763

Summary

MIR6763 (microRNA 6763, HGNC:50139) is a microRNA gene on chromosome 12q24.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465975 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50139
Approved symbol	MIR6763
Name	microRNA 6763
Location	12q24.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6763
Ensembl gene	ENSG00000277052
Ensembl biotype	miRNA
Entrez	102465975
RNAcentral	URS0000759B20 — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612332

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612332 — 1 exons

Exon	Start	End
ENSE00003729725	132581997	132582061

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 80.17.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.17	gold quality
adrenal tissue	UBERON:0018303	76.89	gold quality
monocyte	CL:0000576	76.85	gold quality
endometrium	UBERON:0001295	75.88	gold quality
muscle of leg	UBERON:0001383	75.66	gold quality
gastrocnemius	UBERON:0001388	75.26	gold quality
blood	UBERON:0000178	75.07	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.54	gold quality
body of stomach	UBERON:0001161	73.46	gold quality
heart left ventricle	UBERON:0002084	73.44	gold quality
right hemisphere of cerebellum	UBERON:0014890	73.24	gold quality
stomach	UBERON:0000945	73.23	gold quality
body of pancreas	UBERON:0001150	72.81	gold quality
granulocyte	CL:0000094	72.79	gold quality
right lobe of liver	UBERON:0001114	72.62	gold quality
liver	UBERON:0002107	72.43	gold quality
heart	UBERON:0000948	72.06	gold quality
popliteal artery	UBERON:0002250	71.84	gold quality
tibial artery	UBERON:0007610	71.78	gold quality
skin of abdomen	UBERON:0001416	71.52	gold quality
prefrontal cortex	UBERON:0000451	71.44	gold quality
mucosa of transverse colon	UBERON:0004991	71.41	gold quality
transverse colon	UBERON:0001157	71.36	gold quality
smooth muscle tissue	UBERON:0001135	71.29	gold quality
cerebellar hemisphere	UBERON:0002245	71.14	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.07	gold quality
right atrium auricular region	UBERON:0006631	70.92	gold quality
intestine	UBERON:0000160	70.66	gold quality
colon	UBERON:0001155	70.66	gold quality
small intestine Peyer’s patch	UBERON:0003454	70.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.