MIR6764

Summary

MIR6764 (microRNA 6764, HGNC:49994) is a microRNA gene on chromosome 14q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466730 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49994
Approved symbol	MIR6764
Name	microRNA 6764
Location	14q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6764
Ensembl gene	ENSG00000283840
Ensembl biotype	miRNA
Entrez	102466730
RNAcentral	URS000075C18F — ncRNA, 61 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636393

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636393 — 1 exons

Exon	Start	End
ENSE00003794970	100277357	100277417

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 69.24.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	69.24	gold quality
putamen	UBERON:0001874	61.01	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.24	gold quality
transverse colon	UBERON:0001157	58.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.28	gold quality
caudate nucleus	UBERON:0001873	55.17	gold quality
skin of abdomen	UBERON:0001416	54.68	gold quality
skin of leg	UBERON:0001511	49.92	gold quality
cerebellar hemisphere	UBERON:0002245	44.99	silver quality
lower esophagus muscularis layer	UBERON:0035833	44.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.