MIR6765

Summary

MIR6765 (microRNA 6765, HGNC:50030) is a microRNA gene on chromosome 14q32.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465458 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50030
Approved symbol	MIR6765
Name	microRNA 6765
Location	14q32.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6765
Ensembl gene	ENSG00000273778
Ensembl biotype	miRNA
Entrez	102465458
RNAcentral	URS000075DF12 — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614092

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614092 — 1 exons

Exon	Start	End
ENSE00003730361	105150778	105150864

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 75.71.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	75.71	gold quality
muscle of leg	UBERON:0001383	74.27	gold quality
gastrocnemius	UBERON:0001388	74.10	gold quality
right lobe of liver	UBERON:0001114	73.58	gold quality
heart left ventricle	UBERON:0002084	71.88	gold quality
heart	UBERON:0000948	70.28	gold quality
blood	UBERON:0000178	70.00	gold quality
right atrium auricular region	UBERON:0006631	69.45	gold quality
adrenal gland	UBERON:0002369	68.98	gold quality
body of stomach	UBERON:0001161	68.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.12	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.73	gold quality
left adrenal gland	UBERON:0001234	67.46	gold quality
prefrontal cortex	UBERON:0000451	67.45	gold quality
tibial artery	UBERON:0007610	67.44	gold quality
right frontal lobe	UBERON:0002810	67.24	gold quality
amygdala	UBERON:0001876	67.06	gold quality
left coronary artery	UBERON:0001626	66.57	gold quality
body of pancreas	UBERON:0001150	66.54	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.50	gold quality
skin of abdomen	UBERON:0001416	66.47	gold quality
apex of heart	UBERON:0002098	66.34	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.23	gold quality
substantia nigra	UBERON:0002038	66.21	gold quality
transverse colon	UBERON:0001157	66.15	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.03	gold quality
myometrium	UBERON:0001296	66.01	gold quality
left adrenal gland cortex	UBERON:0035825	65.99	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.86	gold quality
esophagus mucosa	UBERON:0002469	65.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.