MIR6766

Summary

MIR6766 (microRNA 6766, HGNC:49941) is a microRNA gene on chromosome 15q26.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466983 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49941
Approved symbol	MIR6766
Name	microRNA 6766
Location	15q26.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6766
Ensembl gene	ENSG00000275101
Ensembl biotype	miRNA
Entrez	102466983
RNAcentral	URS000075D0C1 — ncRNA, 72 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622641

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622641 — 1 exons

Exon	Start	End
ENSE00003713545	89326739	89326810

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 89.90.

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.90	gold quality
vermiform appendix	UBERON:0001154	87.51	gold quality
bone marrow	UBERON:0002371	86.04	gold quality
calcaneal tendon	UBERON:0003701	84.84	gold quality
duodenum	UBERON:0002114	84.35	gold quality
monocyte	CL:0000576	78.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.60	gold quality
adrenal tissue	UBERON:0018303	75.90	gold quality
blood	UBERON:0000178	75.89	gold quality
muscle of leg	UBERON:0001383	75.06	gold quality
adult mammalian kidney	UBERON:0000082	74.99	gold quality
fundus of stomach	UBERON:0001160	74.00	gold quality
gastrocnemius	UBERON:0001388	73.97	gold quality
endometrium	UBERON:0001295	73.12	gold quality
heart left ventricle	UBERON:0002084	72.90	gold quality
liver	UBERON:0002107	72.67	gold quality
lymph node	UBERON:0000029	72.56	gold quality
kidney	UBERON:0002113	72.56	gold quality
islet of Langerhans	UBERON:0000006	72.51	gold quality
heart	UBERON:0000948	71.74	gold quality
stomach	UBERON:0000945	70.93	gold quality
body of stomach	UBERON:0001161	69.89	gold quality
tibial artery	UBERON:0007610	69.76	gold quality
descending thoracic aorta	UBERON:0002345	69.70	gold quality
ascending aorta	UBERON:0001496	69.57	gold quality
urinary bladder	UBERON:0001255	69.47	gold quality
right atrium auricular region	UBERON:0006631	69.35	gold quality
right lobe of liver	UBERON:0001114	69.34	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.18	gold quality
left coronary artery	UBERON:0001626	69.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.