MIR6767

Summary

MIR6767 (microRNA 6767, HGNC:50133) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465459 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50133
Approved symbol	MIR6767
Name	microRNA 6767
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6767
Ensembl gene	ENSG00000283180
Ensembl biotype	miRNA
Entrez	102465459
RNAcentral	URS000075B212 — miRNA, 66 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637302

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637302 — 1 exons

Exon	Start	End
ENSE00003797374	2445392	2445457

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 78.34.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.34	gold quality
heart left ventricle	UBERON:0002084	73.30	gold quality
heart	UBERON:0000948	72.43	gold quality
gastrocnemius	UBERON:0001388	72.22	gold quality
smooth muscle tissue	UBERON:0001135	71.13	gold quality
stomach	UBERON:0000945	70.72	gold quality
endometrium	UBERON:0001295	70.59	gold quality
body of stomach	UBERON:0001161	69.13	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.64	gold quality
lung	UBERON:0002048	68.44	gold quality
body of pancreas	UBERON:0001150	68.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.70	gold quality
amygdala	UBERON:0001876	67.68	gold quality
left adrenal gland cortex	UBERON:0035825	67.06	gold quality
thoracic aorta	UBERON:0001515	66.96	gold quality
skin of abdomen	UBERON:0001416	66.81	gold quality
ascending aorta	UBERON:0001496	66.43	gold quality
right atrium auricular region	UBERON:0006631	66.36	gold quality
nucleus accumbens	UBERON:0001882	66.26	gold quality
vagina	UBERON:0000996	66.17	gold quality
ectocervix	UBERON:0012249	65.94	gold quality
transverse colon	UBERON:0001157	65.84	gold quality
Ammon’s horn	UBERON:0001954	65.23	gold quality
myometrium	UBERON:0001296	65.18	gold quality
intestine	UBERON:0000160	65.04	gold quality
left ovary	UBERON:0002119	64.99	gold quality
esophagus mucosa	UBERON:0002469	64.87	gold quality
skin of leg	UBERON:0001511	64.78	gold quality
body of uterus	UBERON:0009853	64.32	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.