MIR6768

Summary

MIR6768 (microRNA 6768, HGNC:50264) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465460 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50264
Approved symbol	MIR6768
Name	microRNA 6768
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6768
Ensembl gene	ENSG00000274805
Ensembl biotype	miRNA
Entrez	102465460
RNAcentral	URS000075DC34 — ncRNA, 72 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610734

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610734 — 1 exons

Exon	Start	End
ENSE00003724110	2463967	2464038

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 77.45.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	77.45	gold quality
blood	UBERON:0000178	74.87	gold quality
gastrocnemius	UBERON:0001388	73.38	gold quality
liver	UBERON:0002107	72.65	gold quality
right lobe of liver	UBERON:0001114	71.46	gold quality
stomach	UBERON:0000945	70.52	gold quality
rectum	UBERON:0001052	69.46	gold quality
endometrium	UBERON:0001295	69.24	gold quality
tibial artery	UBERON:0007610	69.21	gold quality
heart left ventricle	UBERON:0002084	68.84	gold quality
Ammon’s horn	UBERON:0001954	68.25	gold quality
body of stomach	UBERON:0001161	68.22	gold quality
substantia nigra	UBERON:0002038	67.69	gold quality
body of pancreas	UBERON:0001150	67.47	gold quality
lung	UBERON:0002048	67.05	gold quality
heart	UBERON:0000948	66.90	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.43	gold quality
right atrium auricular region	UBERON:0006631	66.11	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.06	gold quality
fundus of stomach	UBERON:0001160	65.99	gold quality
left adrenal gland	UBERON:0001234	65.89	gold quality
putamen	UBERON:0001874	65.79	gold quality
anterior cingulate cortex	UBERON:0009835	65.71	gold quality
cerebral cortex	UBERON:0000956	65.67	gold quality
right frontal lobe	UBERON:0002810	65.58	gold quality
transverse colon	UBERON:0001157	65.46	gold quality
ascending aorta	UBERON:0001496	65.39	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.39	gold quality
upper lobe of left lung	UBERON:0008952	65.20	gold quality
esophagus mucosa	UBERON:0002469	65.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.