MIR6769A

Summary

MIR6769A (microRNA 6769a, HGNC:50079) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466731 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50079
Approved symbol	MIR6769A
Name	microRNA 6769a
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6769a
Ensembl gene	ENSG00000276641
Ensembl biotype	miRNA
Entrez	102466731
RNAcentral	URS000075C3A8 — ncRNA, 73 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617340

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617340 — 1 exons

Exon	Start	End
ENSE00003731952	4671318	4671390

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 88.55.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	88.55	gold quality
vermiform appendix	UBERON:0001154	84.71	gold quality
bone marrow	UBERON:0002371	84.09	gold quality
adrenal tissue	UBERON:0018303	82.99	gold quality
monocyte	CL:0000576	80.18	gold quality
blood	UBERON:0000178	79.99	gold quality
prefrontal cortex	UBERON:0000451	77.52	gold quality
calcaneal tendon	UBERON:0003701	76.80	gold quality
liver	UBERON:0002107	75.81	gold quality
muscle of leg	UBERON:0001383	75.45	gold quality
lymph node	UBERON:0000029	75.02	gold quality
placenta	UBERON:0001987	74.61	gold quality
gastrocnemius	UBERON:0001388	74.50	gold quality
fundus of stomach	UBERON:0001160	73.61	gold quality
islet of Langerhans	UBERON:0000006	73.42	gold quality
stomach	UBERON:0000945	72.44	gold quality
granulocyte	CL:0000094	72.35	gold quality
lung	UBERON:0002048	72.35	gold quality
endometrium	UBERON:0001295	72.15	gold quality
upper lobe of left lung	UBERON:0008952	72.12	gold quality
body of stomach	UBERON:0001161	72.05	gold quality
right lobe of thyroid gland	UBERON:0001119	72.01	gold quality
tibial artery	UBERON:0007610	71.72	gold quality
skin of leg	UBERON:0001511	71.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.47	gold quality
lower esophagus	UBERON:0013473	71.38	gold quality
body of pancreas	UBERON:0001150	71.17	gold quality
heart left ventricle	UBERON:0002084	71.12	gold quality
zone of skin	UBERON:0000014	70.97	gold quality
right atrium auricular region	UBERON:0006631	70.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.