MIR6769B

Summary

MIR6769B (microRNA 6769b, HGNC:50016) is a microRNA gene on chromosome 1q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466202 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50016
Approved symbol	MIR6769B
Name	microRNA 6769b
Location	1q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6769b
Ensembl gene	ENSG00000278465
Ensembl biotype	miRNA
Entrez	102466202
RNAcentral	URS000075B1DF — ncRNA, 62 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622159

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622159 — 1 exons

Exon	Start	End
ENSE00003743838	206474803	206474864

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 98.38.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.38	gold quality
heart	UBERON:0000948	76.93	gold quality
blood	UBERON:0000178	73.39	gold quality
skin of abdomen	UBERON:0001416	72.85	gold quality
gastrocnemius	UBERON:0001388	71.93	gold quality
right lobe of liver	UBERON:0001114	69.23	gold quality
body of stomach	UBERON:0001161	68.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.49	gold quality
ascending aorta	UBERON:0001496	66.36	gold quality
skin of leg	UBERON:0001511	65.99	gold quality
esophagus mucosa	UBERON:0002469	65.39	gold quality
endometrium	UBERON:0001295	65.27	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.48	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.07	gold quality
thyroid gland	UBERON:0002046	62.86	gold quality
spleen	UBERON:0002106	62.23	gold quality
transverse colon	UBERON:0001157	62.18	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.33	gold quality
left testis	UBERON:0004533	43.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.