MIR6770-3

Summary

MIR6770-3 (microRNA 6770-3, HGNC:50034) is a microRNA gene on chromosome 16p12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466259 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50034
Approved symbol	MIR6770-3
Name	microRNA 6770-3
Location	16p12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6770-3
Ensembl gene	ENSG00000275391
Ensembl biotype	miRNA
Entrez	102466259
RNAcentral	URS000075B619 — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616362

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616362 — 1 exons

Exon	Start	End
ENSE00003716594	18379351	18379410

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 94.95.

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.95	gold quality
skeletal muscle tissue	UBERON:0001134	78.31	gold quality
adrenal tissue	UBERON:0018303	72.40	gold quality
bone marrow	UBERON:0002371	72.34	gold quality
prefrontal cortex	UBERON:0000451	70.24	gold quality
blood	UBERON:0000178	68.40	gold quality
apex of heart	UBERON:0002098	68.15	gold quality
monocyte	CL:0000576	67.61	gold quality
muscle of leg	UBERON:0001383	66.84	gold quality
gastrocnemius	UBERON:0001388	66.31	gold quality
islet of Langerhans	UBERON:0000006	64.67	gold quality
smooth muscle tissue	UBERON:0001135	63.01	gold quality
calcaneal tendon	UBERON:0003701	62.50	gold quality
heart left ventricle	UBERON:0002084	62.29	gold quality
tibial artery	UBERON:0007610	62.02	gold quality
popliteal artery	UBERON:0002250	61.96	gold quality
endometrium	UBERON:0001295	61.93	gold quality
liver	UBERON:0002107	61.33	gold quality
body of pancreas	UBERON:0001150	61.29	gold quality
body of stomach	UBERON:0001161	60.94	gold quality
cerebellar hemisphere	UBERON:0002245	60.68	gold quality
stomach	UBERON:0000945	60.56	gold quality
thoracic aorta	UBERON:0001515	60.54	gold quality
ascending aorta	UBERON:0001496	60.53	gold quality
right lobe of liver	UBERON:0001114	60.40	gold quality
heart	UBERON:0000948	60.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	59.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.79	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.40	gold quality
right hemisphere of cerebellum	UBERON:0014890	59.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (2): MIR6770-2 (ENSG00000277698), MIR6770-1 (ENSG00000278265)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.