MIR6771

Summary

MIR6771 (microRNA 6771, HGNC:50212) is a microRNA gene on chromosome 16q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465462 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50212
Approved symbol	MIR6771
Name	microRNA 6771
Location	16q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6771
Ensembl gene	ENSG00000274969
Ensembl biotype	miRNA
Entrez	102465462
RNAcentral	URS000075ADA8 — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619793

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619793 — 1 exons

Exon	Start	End
ENSE00003719571	50292616	50292675

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 80.66.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	80.66	gold quality
blood	UBERON:0000178	78.36	gold quality
bone marrow	UBERON:0002371	76.99	gold quality
monocyte	CL:0000576	73.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.42	gold quality
gastrocnemius	UBERON:0001388	71.72	gold quality
calcaneal tendon	UBERON:0003701	70.52	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.29	gold quality
body of stomach	UBERON:0001161	68.78	gold quality
esophagus mucosa	UBERON:0002469	68.53	gold quality
omental fat pad	UBERON:0010414	67.98	gold quality
endometrium	UBERON:0001295	67.86	gold quality
ascending aorta	UBERON:0001496	67.68	gold quality
upper lobe of left lung	UBERON:0008952	67.53	gold quality
transverse colon	UBERON:0001157	66.54	gold quality
caudate nucleus	UBERON:0001873	66.12	gold quality
skin of leg	UBERON:0001511	66.00	gold quality
liver	UBERON:0002107	65.31	gold quality
myometrium	UBERON:0001296	64.97	gold quality
skin of abdomen	UBERON:0001416	64.72	gold quality
minor salivary gland	UBERON:0001830	64.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.12	gold quality
thyroid gland	UBERON:0002046	63.98	gold quality
left ovary	UBERON:0002119	63.58	gold quality
prostate gland	UBERON:0002367	63.48	gold quality
left lobe of thyroid gland	UBERON:0001120	63.11	gold quality
body of uterus	UBERON:0009853	62.48	gold quality
spleen	UBERON:0002106	61.36	gold quality
tibial nerve	UBERON:0001323	60.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.