MIR6772

Summary

MIR6772 (microRNA 6772, HGNC:50064) is a microRNA gene on chromosome 16q21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465463 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50064
Approved symbol	MIR6772
Name	microRNA 6772
Location	16q21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6772
Ensembl gene	ENSG00000274816
Ensembl biotype	miRNA
Entrez	102465463
RNAcentral	URS000075B02F — ncRNA, 64 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616699

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616699 — 1 exons

Exon	Start	End
ENSE00003730186	57772289	57772352

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 96.34.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
metanephros cortex	UBERON:0010533	96.34	gold quality
sural nerve	UBERON:0015488	95.97	gold quality
body of pancreas	UBERON:0001150	91.71	gold quality
right lobe of thyroid gland	UBERON:0001119	91.45	gold quality
skeletal muscle tissue	UBERON:0001134	90.23	gold quality
pancreas	UBERON:0001264	89.66	gold quality
left lobe of thyroid gland	UBERON:0001120	89.42	gold quality
thyroid gland	UBERON:0002046	89.33	gold quality
vermiform appendix	UBERON:0001154	88.49	gold quality
kidney	UBERON:0002113	87.41	gold quality
right lobe of liver	UBERON:0001114	87.08	gold quality
duodenum	UBERON:0002114	86.24	gold quality
liver	UBERON:0002107	85.66	gold quality
adult mammalian kidney	UBERON:0000082	85.32	gold quality
skin of leg	UBERON:0001511	84.49	gold quality
zone of skin	UBERON:0000014	83.62	gold quality
lymph node	UBERON:0000029	83.27	gold quality
lung	UBERON:0002048	82.76	gold quality
upper lobe of left lung	UBERON:0008952	82.66	gold quality
skin of abdomen	UBERON:0001416	82.35	gold quality
small intestine	UBERON:0002108	81.66	gold quality
granulocyte	CL:0000094	81.48	gold quality
small intestine Peyer’s patch	UBERON:0003454	81.17	gold quality
apex of heart	UBERON:0002098	80.74	gold quality
right lung	UBERON:0002167	80.37	gold quality
placenta	UBERON:0001987	80.01	gold quality
body of stomach	UBERON:0001161	79.94	gold quality
stomach	UBERON:0000945	79.24	gold quality
lower esophagus mucosa	UBERON:0035834	79.24	gold quality
heart left ventricle	UBERON:0002084	79.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.