MIR6773

Summary

MIR6773 (microRNA 6773, HGNC:50132) is a microRNA gene on chromosome 16q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466194 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50132
Approved symbol	MIR6773
Name	microRNA 6773
Location	16q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6773
Ensembl gene	ENSG00000284259
Ensembl biotype	miRNA
Entrez	102466194
RNAcentral	URS000075A041 — ncRNA, 74 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612812

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612812 — 1 exons

Exon	Start	End
ENSE00003731077	68233426	68233499

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 77.48.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.48	gold quality
gastrocnemius	UBERON:0001388	72.93	gold quality
islet of Langerhans	UBERON:0000006	68.90	gold quality
hypothalamus	UBERON:0001898	66.69	gold quality
omental fat pad	UBERON:0010414	64.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.26	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.96	gold quality
spleen	UBERON:0002106	60.26	gold quality
thyroid gland	UBERON:0002046	48.27	gold quality
small intestine Peyer’s patch	UBERON:0003454	46.23	gold quality
skin of abdomen	UBERON:0001416	34.71	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.