MIR6774

Summary

MIR6774 (microRNA 6774, HGNC:50202) is a microRNA gene on chromosome 16q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466732 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50202
Approved symbol	MIR6774
Name	microRNA 6774
Location	16q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6774
Ensembl gene	ENSG00000274134
Ensembl biotype	miRNA
Entrez	102466732
RNAcentral	URS000075C64E — ncRNA, 70 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614651

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614651 — 1 exons

Exon	Start	End
ENSE00003738638	85918347	85918416

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 96.05.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tonsil	UBERON:0002372	96.05	gold quality
monocyte	CL:0000576	90.89	gold quality
vermiform appendix	UBERON:0001154	90.53	gold quality
leukocyte	CL:0000738	90.48	gold quality
lymph node	UBERON:0000029	89.78	gold quality
bone marrow	UBERON:0002371	89.20	gold quality
granulocyte	CL:0000094	88.56	gold quality
spleen	UBERON:0002106	87.12	gold quality
rectum	UBERON:0001052	85.20	gold quality
duodenum	UBERON:0002114	85.11	gold quality
sural nerve	UBERON:0015488	83.75	gold quality
small intestine	UBERON:0002108	83.07	gold quality
small intestine Peyer’s patch	UBERON:0003454	83.01	gold quality
placenta	UBERON:0001987	81.95	gold quality
blood	UBERON:0000178	81.01	gold quality
prefrontal cortex	UBERON:0000451	78.84	gold quality
adrenal tissue	UBERON:0018303	78.79	gold quality
smooth muscle tissue	UBERON:0001135	78.20	gold quality
liver	UBERON:0002107	77.31	gold quality
intestine	UBERON:0000160	76.44	gold quality
right lobe of liver	UBERON:0001114	75.46	gold quality
muscle of leg	UBERON:0001383	75.15	gold quality
transverse colon	UBERON:0001157	74.68	gold quality
mucosa of transverse colon	UBERON:0004991	74.56	gold quality
subcutaneous adipose tissue	UBERON:0002190	74.07	gold quality
fundus of stomach	UBERON:0001160	74.03	gold quality
gastrocnemius	UBERON:0001388	73.63	gold quality
adipose tissue	UBERON:0001013	73.58	gold quality
stomach	UBERON:0000945	73.52	gold quality
body of stomach	UBERON:0001161	73.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.63

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.