MIR6775

Summary

MIR6775 (microRNA 6775, HGNC:50100) is a microRNA gene on chromosome 16q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465464 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50100
Approved symbol	MIR6775
Name	microRNA 6775
Location	16q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6775
Ensembl gene	ENSG00000278598
Ensembl biotype	miRNA
Entrez	102465464
RNAcentral	URS000075DEA5 — ncRNA, 69 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617557

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617557 — 1 exons

Exon	Start	End
ENSE00003738943	87834592	87834660

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 87.17.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	87.17	gold quality
myometrium	UBERON:0001296	86.35	gold quality
monocyte	CL:0000576	85.57	gold quality
vermiform appendix	UBERON:0001154	84.10	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.34	gold quality
gall bladder	UBERON:0002110	77.37	gold quality
mucosa of stomach	UBERON:0001199	76.24	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.00	gold quality
muscle of leg	UBERON:0001383	75.72	gold quality
gastrocnemius	UBERON:0001388	75.54	gold quality
blood	UBERON:0000178	74.93	gold quality
lymph node	UBERON:0000029	74.42	gold quality
fundus of stomach	UBERON:0001160	74.09	gold quality
placenta	UBERON:0001987	73.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.39	gold quality
body of stomach	UBERON:0001161	72.74	gold quality
islet of Langerhans	UBERON:0000006	72.61	gold quality
stomach	UBERON:0000945	72.51	gold quality
lower esophagus mucosa	UBERON:0035834	72.49	gold quality
right lobe of liver	UBERON:0001114	72.04	gold quality
right frontal lobe	UBERON:0002810	71.84	gold quality
frontal cortex	UBERON:0001870	71.65	gold quality
adenohypophysis	UBERON:0002196	71.39	gold quality
esophagus mucosa	UBERON:0002469	71.15	gold quality
substantia nigra	UBERON:0002038	71.01	gold quality
prefrontal cortex	UBERON:0000451	70.98	gold quality
right atrium auricular region	UBERON:0006631	70.96	gold quality
liver	UBERON:0002107	70.76	gold quality
Ammon’s horn	UBERON:0001954	70.72	gold quality
esophagus	UBERON:0001043	70.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.03

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Tumor suppressive miR-6775-3p inhibits esophageal squamous cell carcinoma progression through forming a positive feedback loop with p53 via MAGE-A family proteins. (PMID:30333480)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.