MIR6777

Summary

MIR6777 (microRNA 6777, HGNC:50173) is a microRNA gene on chromosome 17p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465466 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50173
Approved symbol	MIR6777
Name	microRNA 6777
Location	17p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6777
Ensembl gene	ENSG00000274111
Ensembl biotype	miRNA
Entrez	102465466
RNAcentral	URS0000759A65 — ncRNA, 66 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613934

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613934 — 1 exons

Exon	Start	End
ENSE00003723166	17813480	17813545

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 89.89.

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	89.89	gold quality
lymph node	UBERON:0000029	81.17	gold quality
bone marrow	UBERON:0002371	81.13	gold quality
sural nerve	UBERON:0015488	80.18	gold quality
liver	UBERON:0002107	77.17	gold quality
adrenal tissue	UBERON:0018303	77.08	gold quality
right lobe of liver	UBERON:0001114	76.81	gold quality
left adrenal gland cortex	UBERON:0035825	76.24	gold quality
muscle of leg	UBERON:0001383	76.16	gold quality
urinary bladder	UBERON:0001255	75.11	gold quality
left adrenal gland	UBERON:0001234	74.98	gold quality
mucosa of transverse colon	UBERON:0004991	74.78	gold quality
gall bladder	UBERON:0002110	74.54	gold quality
blood	UBERON:0000178	74.29	gold quality
gastrocnemius	UBERON:0001388	74.03	gold quality
adrenal gland	UBERON:0002369	73.98	gold quality
right adrenal gland cortex	UBERON:0035827	73.28	gold quality
ectocervix	UBERON:0012249	72.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.82	gold quality
right adrenal gland	UBERON:0001233	71.63	gold quality
prefrontal cortex	UBERON:0000451	71.36	gold quality
heart left ventricle	UBERON:0002084	71.33	gold quality
amygdala	UBERON:0001876	71.29	gold quality
left coronary artery	UBERON:0001626	71.13	gold quality
heart	UBERON:0000948	70.98	gold quality
body of pancreas	UBERON:0001150	70.83	gold quality
stomach	UBERON:0000945	70.68	gold quality
right atrium auricular region	UBERON:0006631	70.51	gold quality
apex of heart	UBERON:0002098	70.43	gold quality
body of stomach	UBERON:0001161	70.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.