MIR6778

Summary

MIR6778 (microRNA 6778, HGNC:50183) is a microRNA gene on chromosome 17p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466733 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50183
Approved symbol	MIR6778
Name	microRNA 6778
Location	17p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6778
Ensembl gene	ENSG00000283772
Ensembl biotype	miRNA
Entrez	102466733
RNAcentral	URS000075E4AA — ncRNA, 73 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617912

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617912 — 1 exons

Exon	Start	End
ENSE00003719020	18340814	18340886

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 71.53.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of stomach	UBERON:0001161	71.53	gold quality
colon	UBERON:0001155	64.20	gold quality
left adrenal gland	UBERON:0001234	62.24	gold quality
putamen	UBERON:0001874	61.91	gold quality
hypothalamus	UBERON:0001898	61.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.70	gold quality
right frontal lobe	UBERON:0002810	60.76	gold quality
nucleus accumbens	UBERON:0001882	56.33	gold quality
left ovary	UBERON:0002119	55.30	gold quality
body of pancreas	UBERON:0001150	54.10	gold quality
omental fat pad	UBERON:0010414	53.04	gold quality
transverse colon	UBERON:0001157	49.96	gold quality
skin of leg	UBERON:0001511	46.45	gold quality
small intestine Peyer’s patch	UBERON:0003454	44.08	gold quality
prostate gland	UBERON:0002367	43.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• the present study revealed that circRNA CBL.11expression is significantly increased in CRC cells after carbon ion irradiation. Functionally and mechanistically, circRNA CBL.11 regulates YWHAE expression by sponging miR-6778-5p directly to suppress cell proliferation in colorectal cancer. (PMID:31438886)
• Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism. (PMID:32142918)
• The Drosha-Independent MicroRNA6778-5p/GSK3beta Axis Mediates the Proliferation of Gastric Cancer Cells. (PMID:36210981)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.