MIR6779

Summary

MIR6779 (microRNA 6779, HGNC:50148) is a microRNA gene on chromosome 17q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465467 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50148
Approved symbol	MIR6779
Name	microRNA 6779
Location	17q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6779
Ensembl gene	ENSG00000277057
Ensembl biotype	miRNA
Entrez	102465467
RNAcentral	URS000075D7CB — miRNA, 64 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617283

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617283 — 1 exons

Exon	Start	End
ENSE00003732885	38914979	38915042

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 82.49.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	82.49	gold quality
rectum	UBERON:0001052	81.38	gold quality
adrenal tissue	UBERON:0018303	77.92	gold quality
monocyte	CL:0000576	76.26	gold quality
blood	UBERON:0000178	75.85	gold quality
heart left ventricle	UBERON:0002084	72.62	gold quality
muscle of leg	UBERON:0001383	72.50	gold quality
heart	UBERON:0000948	72.15	gold quality
mucosa of transverse colon	UBERON:0004991	71.43	gold quality
body of pancreas	UBERON:0001150	71.06	gold quality
right lobe of liver	UBERON:0001114	70.51	gold quality
right atrium auricular region	UBERON:0006631	70.47	gold quality
islet of Langerhans	UBERON:0000006	70.39	gold quality
tibial artery	UBERON:0007610	70.16	gold quality
stomach	UBERON:0000945	69.78	gold quality
left coronary artery	UBERON:0001626	69.63	gold quality
prostate gland	UBERON:0002367	69.48	gold quality
Ammon’s horn	UBERON:0001954	69.37	gold quality
body of stomach	UBERON:0001161	69.32	gold quality
endometrium	UBERON:0001295	69.31	gold quality
urinary bladder	UBERON:0001255	68.70	gold quality
ascending aorta	UBERON:0001496	68.51	gold quality
thoracic aorta	UBERON:0001515	68.44	gold quality
anterior cingulate cortex	UBERON:0009835	68.30	gold quality
fundus of stomach	UBERON:0001160	68.20	gold quality
substantia nigra	UBERON:0002038	68.05	gold quality
transverse colon	UBERON:0001157	67.92	gold quality
adenohypophysis	UBERON:0002196	67.87	gold quality
colon	UBERON:0001155	67.81	gold quality
omental fat pad	UBERON:0010414	67.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA. (PMID:38915053)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.