MIR6780A

Summary

MIR6780A (microRNA 6780a, HGNC:50069) is a microRNA gene on chromosome 17q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466195 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50069
Approved symbol	MIR6780A
Name	microRNA 6780a
Location	17q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6780a
Ensembl gene	ENSG00000275273
Ensembl biotype	miRNA
Entrez	102466195
RNAcentral	URS0000759AB6 — ncRNA, 68 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615089

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615089 — 1 exons

Exon	Start	End
ENSE00003714132	42708084	42708151

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 80.47.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	80.47	gold quality
adrenal tissue	UBERON:0018303	79.17	gold quality
blood	UBERON:0000178	76.70	gold quality
monocyte	CL:0000576	75.45	gold quality
muscle of leg	UBERON:0001383	73.79	gold quality
gastrocnemius	UBERON:0001388	73.08	gold quality
substantia nigra	UBERON:0002038	70.37	gold quality
endometrium	UBERON:0001295	70.00	gold quality
body of pancreas	UBERON:0001150	69.70	gold quality
stomach	UBERON:0000945	69.69	gold quality
urinary bladder	UBERON:0001255	69.67	gold quality
thoracic aorta	UBERON:0001515	69.44	gold quality
ascending aorta	UBERON:0001496	69.19	gold quality
heart left ventricle	UBERON:0002084	69.16	gold quality
right ovary	UBERON:0002118	69.10	gold quality
myometrium	UBERON:0001296	68.98	gold quality
popliteal artery	UBERON:0002250	68.49	gold quality
tibial artery	UBERON:0007610	68.49	gold quality
body of stomach	UBERON:0001161	68.47	gold quality
heart	UBERON:0000948	68.32	gold quality
right lobe of liver	UBERON:0001114	68.09	gold quality
liver	UBERON:0002107	68.01	gold quality
caudate nucleus	UBERON:0001873	67.83	gold quality
right atrium auricular region	UBERON:0006631	67.53	gold quality
ectocervix	UBERON:0012249	67.51	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.97	gold quality
endocervix	UBERON:0000458	66.81	gold quality
amygdala	UBERON:0001876	66.78	gold quality
lung	UBERON:0002048	66.75	gold quality
left adrenal gland	UBERON:0001234	66.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.