MIR6780B

Summary

MIR6780B (microRNA 6780b, HGNC:50237) is a microRNA gene on chromosome 6p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466746 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50237
Approved symbol	MIR6780B
Name	microRNA 6780b
Location	6p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6780b
Ensembl gene	ENSG00000276770
Ensembl biotype	miRNA
Entrez	102466746
RNAcentral	URS000075E778 — ncRNA, 79 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610307

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610307 — 1 exons

Exon	Start	End
ENSE00003727643	43434542	43434620

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 83.50.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	83.50	gold quality
vermiform appendix	UBERON:0001154	82.22	gold quality
adrenal tissue	UBERON:0018303	81.33	gold quality
lymph node	UBERON:0000029	80.00	gold quality
blood	UBERON:0000178	77.96	gold quality
tonsil	UBERON:0002372	74.90	gold quality
monocyte	CL:0000576	74.32	gold quality
endometrium	UBERON:0001295	73.33	gold quality
right adrenal gland cortex	UBERON:0035827	72.94	gold quality
kidney	UBERON:0002113	71.63	gold quality
stomach	UBERON:0000945	71.20	gold quality
muscle of leg	UBERON:0001383	70.97	gold quality
fundus of stomach	UBERON:0001160	70.02	gold quality
body of pancreas	UBERON:0001150	69.55	gold quality
right adrenal gland	UBERON:0001233	69.40	gold quality
gastrocnemius	UBERON:0001388	69.07	gold quality
heart left ventricle	UBERON:0002084	68.97	gold quality
heart	UBERON:0000948	68.72	gold quality
liver	UBERON:0002107	68.64	gold quality
lung	UBERON:0002048	68.30	gold quality
body of stomach	UBERON:0001161	68.17	gold quality
right atrium auricular region	UBERON:0006631	67.85	gold quality
left adrenal gland	UBERON:0001234	67.29	gold quality
granulocyte	CL:0000094	67.22	gold quality
ascending aorta	UBERON:0001496	67.00	gold quality
rectum	UBERON:0001052	66.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.46	gold quality
substantia nigra	UBERON:0002038	66.44	gold quality
Ammon’s horn	UBERON:0001954	66.09	gold quality
colon	UBERON:0001155	66.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Exosomes in ovarian cancer ascites promote epithelial-mesenchymal transition of ovarian cancer cells by delivery of miR-6780b-5p. (PMID:33627627)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.