MIR6781

Summary

MIR6781 (microRNA 6781, HGNC:50185) is a microRNA gene on chromosome 17q21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465468 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50185
Approved symbol	MIR6781
Name	microRNA 6781
Location	17q21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6781
Ensembl gene	ENSG00000278447
Ensembl biotype	miRNA
Entrez	102465468
RNAcentral	URS000075C5BF — ncRNA, 64 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621616

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621616 — 1 exons

Exon	Start	End
ENSE00003747257	42823880	42823943

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 96.97.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.97	gold quality
calcaneal tendon	UBERON:0003701	85.75	gold quality
bone marrow	UBERON:0002371	81.24	gold quality
blood	UBERON:0000178	77.75	gold quality
adrenal tissue	UBERON:0018303	77.26	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.05	gold quality
muscle of leg	UBERON:0001383	75.92	gold quality
gastrocnemius	UBERON:0001388	73.96	gold quality
monocyte	CL:0000576	73.92	gold quality
islet of Langerhans	UBERON:0000006	73.55	gold quality
smooth muscle tissue	UBERON:0001135	71.35	gold quality
stomach	UBERON:0000945	70.67	gold quality
body of stomach	UBERON:0001161	69.78	gold quality
heart left ventricle	UBERON:0002084	69.48	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.14	gold quality
right lobe of liver	UBERON:0001114	68.85	gold quality
right atrium auricular region	UBERON:0006631	68.58	gold quality
metanephros cortex	UBERON:0010533	68.52	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.37	gold quality
right adrenal gland	UBERON:0001233	68.34	gold quality
tibial artery	UBERON:0007610	68.28	gold quality
thoracic aorta	UBERON:0001515	68.10	gold quality
adult mammalian kidney	UBERON:0000082	67.78	gold quality
left adrenal gland cortex	UBERON:0035825	67.74	gold quality
ascending aorta	UBERON:0001496	67.71	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.67	gold quality
body of uterus	UBERON:0009853	67.66	gold quality
left coronary artery	UBERON:0001626	67.59	gold quality
granulocyte	CL:0000094	67.57	gold quality
right lobe of thyroid gland	UBERON:0001119	67.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.44

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.