MIR6782

Summary

MIR6782 (microRNA 6782, HGNC:50270) is a microRNA gene on chromosome 17q21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465469 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50270
Approved symbol	MIR6782
Name	microRNA 6782
Location	17q21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6782
Ensembl gene	ENSG00000275107
Ensembl biotype	miRNA
Entrez	102465469
RNAcentral	URS000075D2C4 — ncRNA, 69 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619539

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619539 — 1 exons

Exon	Start	End
ENSE00003717819	44207771	44207839

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 78.63.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	78.63	gold quality
muscle of leg	UBERON:0001383	76.56	gold quality
sural nerve	UBERON:0015488	75.48	gold quality
blood	UBERON:0000178	74.34	gold quality
lymph node	UBERON:0000029	73.51	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.17	gold quality
prefrontal cortex	UBERON:0000451	71.53	gold quality
gastrocnemius	UBERON:0001388	71.38	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.45	gold quality
stomach	UBERON:0000945	70.08	gold quality
heart left ventricle	UBERON:0002084	69.84	gold quality
body of stomach	UBERON:0001161	69.52	gold quality
tibial artery	UBERON:0007610	68.99	gold quality
body of pancreas	UBERON:0001150	68.70	gold quality
right lobe of liver	UBERON:0001114	68.67	gold quality
right atrium auricular region	UBERON:0006631	68.46	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.02	gold quality
esophagus mucosa	UBERON:0002469	66.66	gold quality
left adrenal gland	UBERON:0001234	66.58	gold quality
endometrium	UBERON:0001295	66.46	gold quality
thoracic mammary gland	UBERON:0005200	66.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.34	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.30	gold quality
left coronary artery	UBERON:0001626	66.28	gold quality
left adrenal gland cortex	UBERON:0035825	66.24	gold quality
Ammon’s horn	UBERON:0001954	66.00	gold quality
transverse colon	UBERON:0001157	65.96	gold quality
cerebral cortex	UBERON:0000956	65.87	gold quality
omental fat pad	UBERON:0010414	65.81	gold quality
ascending aorta	UBERON:0001496	65.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.