MIR6783

Summary

MIR6783 (microRNA 6783, HGNC:50159) is a microRNA gene on chromosome 17q21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466734 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50159
Approved symbol	MIR6783
Name	microRNA 6783
Location	17q21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6783
Ensembl gene	ENSG00000278223
Ensembl biotype	miRNA
Entrez	102466734
RNAcentral	URS000075E610 — miRNA, 64 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619908

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619908 — 1 exons

Exon	Start	End
ENSE00003749236	44934618	44934681

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 93.39.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
quadriceps femoris	UBERON:0001377	93.39	gold quality
frontal cortex	UBERON:0001870	91.38	gold quality
caudate nucleus	UBERON:0001873	91.02	gold quality
cerebellar vermis	UBERON:0004720	90.56	gold quality
bone marrow	UBERON:0002371	85.87	gold quality
lymph node	UBERON:0000029	82.88	gold quality
monocyte	CL:0000576	82.30	gold quality
skeletal muscle tissue	UBERON:0001134	80.75	silver quality
adrenal tissue	UBERON:0018303	78.58	gold quality
myometrium	UBERON:0001296	73.96	gold quality
heart	UBERON:0000948	73.90	gold quality
blood	UBERON:0000178	73.21	gold quality
stomach	UBERON:0000945	72.37	gold quality
right atrium auricular region	UBERON:0006631	71.09	gold quality
kidney	UBERON:0002113	70.91	gold quality
body of stomach	UBERON:0001161	70.41	gold quality
gastrocnemius	UBERON:0001388	69.66	gold quality
endometrium	UBERON:0001295	69.43	gold quality
body of pancreas	UBERON:0001150	69.01	gold quality
right lobe of liver	UBERON:0001114	68.95	gold quality
pancreas	UBERON:0001264	68.89	gold quality
liver	UBERON:0002107	68.84	gold quality
lung	UBERON:0002048	68.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.37	gold quality
heart left ventricle	UBERON:0002084	68.24	gold quality
popliteal artery	UBERON:0002250	67.97	gold quality
left adrenal gland	UBERON:0001234	67.94	gold quality
right adrenal gland	UBERON:0001233	67.80	gold quality
body of uterus	UBERON:0009853	67.66	gold quality
hypothalamus	UBERON:0001898	67.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• rescue assays proved the function of circ_0006427/miR-6783-3p/DKK1 axis in lung adenocarcinoma progression (PMID:30470570)
• Linc01559 Served as a Potential Oncogene and Promoted Resistance of Hepatocellular Carcinoma to Oxaliplatin by Directly Sponging miR-6783-3p. (PMID:32698745)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.