MIR6784

Summary

MIR6784 (microRNA 6784, HGNC:49988) is a microRNA gene on chromosome 17q21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465470 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49988
Approved symbol	MIR6784
Name	microRNA 6784
Location	17q21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6784
Ensembl gene	ENSG00000277249
Ensembl biotype	miRNA
Entrez	102465470
RNAcentral	URS000075CBBA — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611997

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611997 — 1 exons

Exon	Start	End
ENSE00003744291	45114367	45114433

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 91.82.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	91.82	gold quality
placenta	UBERON:0001987	84.22	gold quality
vermiform appendix	UBERON:0001154	84.18	gold quality
mucosa of transverse colon	UBERON:0004991	83.87	gold quality
apex of heart	UBERON:0002098	80.11	gold quality
transverse colon	UBERON:0001157	79.52	gold quality
lower esophagus mucosa	UBERON:0035834	78.79	gold quality
muscle of leg	UBERON:0001383	78.40	gold quality
monocyte	CL:0000576	77.53	gold quality
endometrium	UBERON:0001295	77.35	gold quality
bone marrow	UBERON:0002371	77.01	gold quality
rectum	UBERON:0001052	76.96	gold quality
gastrocnemius	UBERON:0001388	76.69	gold quality
mucosa of stomach	UBERON:0001199	76.66	gold quality
left adrenal gland cortex	UBERON:0035825	76.63	gold quality
sural nerve	UBERON:0015488	76.37	gold quality
prefrontal cortex	UBERON:0000451	76.29	gold quality
heart left ventricle	UBERON:0002084	76.19	gold quality
right coronary artery	UBERON:0001625	76.15	gold quality
adrenal gland	UBERON:0002369	76.01	gold quality
colon	UBERON:0001155	75.85	gold quality
right adrenal gland	UBERON:0001233	75.80	gold quality
left adrenal gland	UBERON:0001234	75.43	gold quality
stomach	UBERON:0000945	75.32	gold quality
heart	UBERON:0000948	75.14	gold quality
body of stomach	UBERON:0001161	74.98	gold quality
fundus of stomach	UBERON:0001160	74.91	gold quality
descending thoracic aorta	UBERON:0002345	74.67	gold quality
intestine	UBERON:0000160	74.35	gold quality
right atrium auricular region	UBERON:0006631	74.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.