MIR6786

Summary

MIR6786 (microRNA 6786, HGNC:49970) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465471 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49970
Approved symbol	MIR6786
Name	microRNA 6786
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6786
Ensembl gene	ENSG00000277784
Ensembl biotype	miRNA
Entrez	102465471
RNAcentral	URS000075CB6A — miRNA, 113 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616843

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616843 — 1 exons

Exon	Start	End
ENSE00003743588	81693757	81693869

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 75.16.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0112 / max 10.8260, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163351	0.0112	3

Top tissues by expression

47 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	75.16	gold quality
blood	UBERON:0000178	74.58	gold quality
gastrocnemius	UBERON:0001388	73.62	gold quality
caudate nucleus	UBERON:0001873	73.48	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.88	gold quality
ectocervix	UBERON:0012249	70.27	gold quality
heart left ventricle	UBERON:0002084	68.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.79	gold quality
colon	UBERON:0001155	68.38	gold quality
ascending aorta	UBERON:0001496	68.38	gold quality
body of stomach	UBERON:0001161	68.10	gold quality
skin of leg	UBERON:0001511	67.61	gold quality
esophagus mucosa	UBERON:0002469	67.48	gold quality
transverse colon	UBERON:0001157	67.29	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.70	gold quality
endometrium	UBERON:0001295	66.64	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.62	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.62	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.01	gold quality
omental fat pad	UBERON:0010414	65.67	gold quality
spleen	UBERON:0002106	65.30	gold quality
adipose tissue	UBERON:0001013	64.67	gold quality
liver	UBERON:0002107	64.65	gold quality
thyroid gland	UBERON:0002046	64.58	gold quality
tibial nerve	UBERON:0001323	64.56	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.23	gold quality
body of uterus	UBERON:0009853	64.06	gold quality
vagina	UBERON:0000996	63.91	gold quality
urinary bladder	UBERON:0001255	63.76	gold quality
skin of abdomen	UBERON:0001416	63.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.