MIR6787

Summary

MIR6787 (microRNA 6787, HGNC:50209) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465472 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50209
Approved symbol	MIR6787
Name	microRNA 6787
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6787
Ensembl gene	ENSG00000284574
Ensembl biotype	miRNA
Entrez	102465472
RNAcentral	URS000075F0F2 — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616675

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616675 — 1 exons

Exon	Start	End
ENSE00003751786	82236668	82236728

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 85.90.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	85.90	gold quality
blood	UBERON:0000178	73.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.02	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.38	gold quality
body of stomach	UBERON:0001161	66.19	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.88	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.78	gold quality
caudate nucleus	UBERON:0001873	62.39	gold quality
ascending aorta	UBERON:0001496	62.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.95	gold quality
cerebellar hemisphere	UBERON:0002245	52.57	gold quality
right ovary	UBERON:0002118	47.80	gold quality
myometrium	UBERON:0001296	43.85	silver quality
skin of leg	UBERON:0001511	42.33	gold quality
spleen	UBERON:0002106	36.95	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.