MIR6788

Summary

MIR6788 (microRNA 6788, HGNC:50078) is a microRNA gene on chromosome 18p11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466735 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50078
Approved symbol	MIR6788
Name	microRNA 6788
Location	18p11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6788
Ensembl gene	ENSG00000274838
Ensembl biotype	miRNA
Entrez	102466735
RNAcentral	URS00007E489B — ncRNA, 66 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618842

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618842 — 1 exons

Exon	Start	End
ENSE00003728671	10759584	10759649

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 74.95.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	74.95	gold quality
stomach	UBERON:0000945	73.67	gold quality
skin of abdomen	UBERON:0001416	72.81	gold quality
lung	UBERON:0002048	69.05	gold quality
body of pancreas	UBERON:0001150	67.47	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.61	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.17	gold quality
upper lobe of left lung	UBERON:0008952	65.67	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.98	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.88	gold quality
skin of leg	UBERON:0001511	64.10	gold quality
Ammon’s horn	UBERON:0001954	63.36	gold quality
prostate gland	UBERON:0002367	63.02	gold quality
left ovary	UBERON:0002119	62.48	gold quality
omental fat pad	UBERON:0010414	61.64	gold quality
left lobe of thyroid gland	UBERON:0001120	61.39	gold quality
esophagus mucosa	UBERON:0002469	61.39	gold quality
spleen	UBERON:0002106	61.30	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.93	gold quality
tibial nerve	UBERON:0001323	60.03	gold quality
pituitary gland	UBERON:0000007	57.80	gold quality
colon	UBERON:0001155	55.50	gold quality
left testis	UBERON:0004533	44.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.