MIR6789

Summary

MIR6789 (microRNA 6789, HGNC:50094) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466736 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50094
Approved symbol	MIR6789
Name	microRNA 6789
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6789
Ensembl gene	ENSG00000284129
Ensembl biotype	miRNA
Entrez	102466736
RNAcentral	URS000075AB7F — ncRNA, 98 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619892

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619892 — 1 exons

Exon	Start	End
ENSE00003739564	2235829	2235926

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 76.41.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.41	gold quality
adrenal gland	UBERON:0002369	76.13	gold quality
stomach	UBERON:0000945	73.70	gold quality
body of stomach	UBERON:0001161	73.58	gold quality
small intestine	UBERON:0002108	72.53	gold quality
gastrocnemius	UBERON:0001388	71.33	gold quality
prefrontal cortex	UBERON:0000451	67.35	gold quality
tibial artery	UBERON:0007610	65.80	gold quality
body of uterus	UBERON:0009853	63.83	gold quality
esophagus mucosa	UBERON:0002469	63.20	gold quality
skin of leg	UBERON:0001511	62.05	gold quality
liver	UBERON:0002107	61.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.58	gold quality
right lung	UBERON:0002167	61.08	gold quality
body of pancreas	UBERON:0001150	61.05	gold quality
heart left ventricle	UBERON:0002084	60.44	gold quality
zone of skin	UBERON:0000014	59.58	gold quality
putamen	UBERON:0001874	58.22	gold quality
ascending aorta	UBERON:0001496	58.17	gold quality
thoracic mammary gland	UBERON:0005200	57.67	gold quality
nucleus accumbens	UBERON:0001882	57.63	gold quality
right atrium auricular region	UBERON:0006631	57.28	gold quality
skin of abdomen	UBERON:0001416	56.86	gold quality
omental fat pad	UBERON:0010414	55.64	gold quality
brain	UBERON:0000955	54.84	gold quality
tibial nerve	UBERON:0001323	54.73	gold quality
caudate nucleus	UBERON:0001873	54.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	54.47	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	54.33	gold quality
anterior cingulate cortex	UBERON:0009835	54.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.