MIR6790

Summary

MIR6790 (microRNA 6790, HGNC:50161) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465473 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50161
Approved symbol	MIR6790
Name	microRNA 6790
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6790
Ensembl gene	ENSG00000273758
Ensembl biotype	miRNA
Entrez	102465473
RNAcentral	URS000075F119 — miRNA, 63 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611058

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611058 — 1 exons

Exon	Start	End
ENSE00003745042	6392921	6392983

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 82.18.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nucleus accumbens	UBERON:0001882	82.18	gold quality
blood	UBERON:0000178	75.79	gold quality
lung	UBERON:0002048	73.36	gold quality
monocyte	CL:0000576	72.03	gold quality
skin of abdomen	UBERON:0001416	71.06	gold quality
ascending aorta	UBERON:0001496	68.51	gold quality
body of stomach	UBERON:0001161	68.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.43	gold quality
hypothalamus	UBERON:0001898	68.07	gold quality
putamen	UBERON:0001874	67.95	gold quality
thoracic mammary gland	UBERON:0005200	67.89	gold quality
esophagus mucosa	UBERON:0002469	67.65	gold quality
skin of leg	UBERON:0001511	67.15	gold quality
anterior cingulate cortex	UBERON:0009835	67.07	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.73	gold quality
amygdala	UBERON:0001876	66.51	gold quality
omental fat pad	UBERON:0010414	66.23	gold quality
tibial artery	UBERON:0007610	65.49	gold quality
left ovary	UBERON:0002119	65.35	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.91	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.71	gold quality
caudate nucleus	UBERON:0001873	64.27	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.93	gold quality
right frontal lobe	UBERON:0002810	63.64	gold quality
right atrium auricular region	UBERON:0006631	63.29	gold quality
cerebellar hemisphere	UBERON:0002245	63.07	gold quality
vagina	UBERON:0000996	62.64	gold quality
transverse colon	UBERON:0001157	62.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.59	gold quality
prostate gland	UBERON:0002367	61.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.