MIR6791

Summary

MIR6791 (microRNA 6791, HGNC:50097) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465474 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50097
Approved symbol	MIR6791
Name	microRNA 6791
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6791
Ensembl gene	ENSG00000283950
Ensembl biotype	miRNA
Entrez	102465474
RNAcentral	URS000075AF60 — ncRNA, 67 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621745

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621745 — 1 exons

Exon	Start	End
ENSE00003753813	6736712	6736778

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 71.93.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	71.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.09	gold quality
ascending aorta	UBERON:0001496	66.30	gold quality
prostate gland	UBERON:0002367	63.56	gold quality
skin of leg	UBERON:0001511	62.53	gold quality
minor salivary gland	UBERON:0001830	62.43	gold quality
tibial artery	UBERON:0007610	61.57	gold quality
esophagus mucosa	UBERON:0002469	60.85	gold quality
transverse colon	UBERON:0001157	60.75	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	60.69	gold quality
omental fat pad	UBERON:0010414	58.89	gold quality
skin of abdomen	UBERON:0001416	58.45	gold quality
anterior cingulate cortex	UBERON:0009835	58.27	gold quality
caudate nucleus	UBERON:0001873	55.36	gold quality
putamen	UBERON:0001874	52.06	gold quality
tibial nerve	UBERON:0001323	45.61	gold quality
myometrium	UBERON:0001296	43.68	silver quality
pituitary gland	UBERON:0000007	43.36	gold quality
left lobe of thyroid gland	UBERON:0001120	39.38	silver quality
thyroid gland	UBERON:0002046	39.27	silver quality
left testis	UBERON:0004533	36.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.