MIR6794

Summary

MIR6794 (microRNA 6794, HGNC:50117) is a microRNA gene on chromosome 19p13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466196 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50117
Approved symbol	MIR6794
Name	microRNA 6794
Location	19p13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6794
Ensembl gene	ENSG00000276181
Ensembl biotype	miRNA
Entrez	102466196
RNAcentral	URS000075A572 — miRNA, 68 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622622

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622622 — 1 exons

Exon	Start	End
ENSE00003731607	12852260	12852327

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 74.87.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	74.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.78	gold quality
Ammon’s horn	UBERON:0001954	67.75	gold quality
substantia nigra	UBERON:0002038	66.17	gold quality
skin of leg	UBERON:0001511	63.19	gold quality
skin of abdomen	UBERON:0001416	63.12	gold quality
omental fat pad	UBERON:0010414	62.36	gold quality
left lobe of thyroid gland	UBERON:0001120	61.61	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.51	gold quality
cerebellar hemisphere	UBERON:0002245	60.88	gold quality
anterior cingulate cortex	UBERON:0009835	60.58	gold quality
pituitary gland	UBERON:0000007	58.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.