MIR6797

Summary

MIR6797 (microRNA 6797, HGNC:50169) is a microRNA gene on chromosome 19q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465478 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50169
Approved symbol	MIR6797
Name	microRNA 6797
Location	19q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6797
Ensembl gene	ENSG00000276926
Ensembl biotype	miRNA
Entrez	102465478
RNAcentral	URS000075A421 — ncRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621706

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621706 — 1 exons

Exon	Start	End
ENSE00003729017	41869627	41869698

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 97.55.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.64	gold quality
adrenal tissue	UBERON:0018303	86.14	gold quality
granulocyte	CL:0000094	85.38	gold quality
right uterine tube	UBERON:0001302	84.46	gold quality
lower esophagus mucosa	UBERON:0035834	84.28	gold quality
duodenum	UBERON:0002114	83.78	gold quality
bone marrow	UBERON:0002371	82.56	gold quality
placenta	UBERON:0001987	79.92	gold quality
blood	UBERON:0000178	79.78	gold quality
vagina	UBERON:0000996	78.88	gold quality
endocervix	UBERON:0000458	78.53	gold quality
monocyte	CL:0000576	78.44	gold quality
liver	UBERON:0002107	77.41	gold quality
left ovary	UBERON:0002119	77.25	gold quality
right lobe of liver	UBERON:0001114	77.24	gold quality
ovary	UBERON:0000992	77.12	gold quality
esophagus mucosa	UBERON:0002469	77.01	gold quality
lymph node	UBERON:0000029	77.00	gold quality
omental fat pad	UBERON:0010414	76.95	gold quality
prostate gland	UBERON:0002367	76.79	gold quality
right ovary	UBERON:0002118	76.60	gold quality
mucosa of transverse colon	UBERON:0004991	76.49	gold quality
skin of abdomen	UBERON:0001416	75.97	gold quality
saliva-secreting gland	UBERON:0001044	75.50	gold quality
heart left ventricle	UBERON:0002084	75.46	gold quality
esophagus	UBERON:0001043	75.41	gold quality
prefrontal cortex	UBERON:0000451	75.38	gold quality
minor salivary gland	UBERON:0001830	75.24	gold quality
gastrocnemius	UBERON:0001388	75.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Thus, PTH stimulated the expression of lnc-SUPT3H-1:16, miR-6797-5p and Runx2, and due to the sponging mechanism of lnc- SUPT3H-1:16 towards miR-6797-5p, Runx2 was protected, resulting in the promotion of osteoblast differentiation. (PMID:30562548)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.