MIR6801

Summary

MIR6801 (microRNA 6801, HGNC:50178) is a microRNA gene on chromosome 19q13.41.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466984 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50178
Approved symbol	MIR6801
Name	microRNA 6801
Location	19q13.41
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6801
Ensembl gene	ENSG00000274380
Ensembl biotype	miRNA
Entrez	102466984
RNAcentral	URS000075CC60 — ncRNA, 79 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614975

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614975 — 1 exons

Exon	Start	End
ENSE00003744881	52222020	52222098

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 96.08.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	96.08	gold quality
right adrenal gland	UBERON:0001233	87.52	gold quality
right adrenal gland cortex	UBERON:0035827	84.79	gold quality
lower esophagus mucosa	UBERON:0035834	82.18	gold quality
bone marrow	UBERON:0002371	81.38	gold quality
lymph node	UBERON:0000029	79.68	gold quality
adrenal gland	UBERON:0002369	79.49	gold quality
blood	UBERON:0000178	77.12	gold quality
left adrenal gland cortex	UBERON:0035825	76.74	gold quality
left adrenal gland	UBERON:0001234	75.77	gold quality
stomach	UBERON:0000945	75.09	gold quality
gastrocnemius	UBERON:0001388	73.24	gold quality
endometrium	UBERON:0001295	72.83	gold quality
kidney	UBERON:0002113	72.82	gold quality
placenta	UBERON:0001987	71.84	gold quality
heart left ventricle	UBERON:0002084	71.04	gold quality
body of stomach	UBERON:0001161	70.76	gold quality
monocyte	CL:0000576	70.59	gold quality
heart	UBERON:0000948	70.44	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.39	gold quality
right atrium auricular region	UBERON:0006631	70.33	gold quality
substantia nigra	UBERON:0002038	70.08	gold quality
corpus callosum	UBERON:0002336	69.58	gold quality
fundus of stomach	UBERON:0001160	69.45	gold quality
lung	UBERON:0002048	69.43	gold quality
body of pancreas	UBERON:0001150	69.14	gold quality
liver	UBERON:0002107	68.75	gold quality
adult mammalian kidney	UBERON:0000082	68.17	gold quality
right lobe of liver	UBERON:0001114	67.98	gold quality
rectum	UBERON:0001052	67.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.