MIR6803

Summary

MIR6803 (microRNA 6803, HGNC:50035) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466739 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50035
Approved symbol	MIR6803
Name	microRNA 6803
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6803
Ensembl gene	ENSG00000278264
Ensembl biotype	miRNA
Entrez	102466739
RNAcentral	URS000075BF8E — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615997

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615997 — 1 exons

Exon	Start	End
ENSE00003730813	55245186	55245250

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 93.69.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.69	gold quality
lymph node	UBERON:0000029	81.34	gold quality
bone marrow	UBERON:0002371	80.17	gold quality
blood	UBERON:0000178	76.35	gold quality
placenta	UBERON:0001987	75.90	gold quality
prefrontal cortex	UBERON:0000451	72.93	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.91	gold quality
heart	UBERON:0000948	72.63	gold quality
heart left ventricle	UBERON:0002084	72.06	gold quality
stomach	UBERON:0000945	69.31	gold quality
right lobe of liver	UBERON:0001114	69.16	gold quality
vagina	UBERON:0000996	69.04	gold quality
right atrium auricular region	UBERON:0006631	68.85	gold quality
tibial artery	UBERON:0007610	68.72	gold quality
Ammon’s horn	UBERON:0001954	68.53	gold quality
ascending aorta	UBERON:0001496	68.49	gold quality
body of stomach	UBERON:0001161	68.31	gold quality
tibial nerve	UBERON:0001323	68.22	gold quality
caudate nucleus	UBERON:0001873	67.93	gold quality
left adrenal gland cortex	UBERON:0035825	67.63	gold quality
left adrenal gland	UBERON:0001234	67.61	gold quality
endometrium	UBERON:0001295	67.59	gold quality
omental fat pad	UBERON:0010414	67.31	gold quality
transverse colon	UBERON:0001157	67.27	gold quality
esophagus mucosa	UBERON:0002469	67.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.64	gold quality
putamen	UBERON:0001874	66.27	gold quality
right adrenal gland	UBERON:0001233	65.70	gold quality
right frontal lobe	UBERON:0002810	65.58	gold quality
spleen	UBERON:0002106	65.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Cox regression analysis revealed high levels of exosomal miR-6803-5p was associated with poor prognosis in colorectal cancer (CRC) independent of other confounding factors. Thus, exosomal miR-6803-5p is a potential diagnostic and prognostic biomarker for patients with CRC. (PMID:29240249)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.