MIR6806

Summary

MIR6806 (microRNA 6806, HGNC:49937) is a microRNA gene on chromosome 19q13.43.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465484 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49937
Approved symbol	MIR6806
Name	microRNA 6806
Location	19q13.43
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6806
Ensembl gene	ENSG00000277588
Ensembl biotype	miRNA
Entrez	102465484
RNAcentral	URS000075DE7E — ncRNA, 64 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622141

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622141 — 1 exons

Exon	Start	End
ENSE00003724623	58334688	58334751

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 82.49.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	82.49	gold quality
pituitary gland	UBERON:0000007	81.45	gold quality
adrenal tissue	UBERON:0018303	79.79	gold quality
adenohypophysis	UBERON:0002196	78.36	gold quality
endometrium	UBERON:0001295	78.11	gold quality
blood	UBERON:0000178	76.64	gold quality
monocyte	CL:0000576	76.31	gold quality
muscle of leg	UBERON:0001383	75.67	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.47	gold quality
mucosa of transverse colon	UBERON:0004991	74.79	gold quality
cerebellar hemisphere	UBERON:0002245	74.34	gold quality
prefrontal cortex	UBERON:0000451	74.28	gold quality
islet of Langerhans	UBERON:0000006	73.74	gold quality
right coronary artery	UBERON:0001625	73.09	gold quality
gastrocnemius	UBERON:0001388	72.61	gold quality
metanephros cortex	UBERON:0010533	72.05	gold quality
brain	UBERON:0000955	72.04	gold quality
ectocervix	UBERON:0012249	72.02	gold quality
heart left ventricle	UBERON:0002084	71.36	gold quality
right adrenal gland	UBERON:0001233	71.05	gold quality
right atrium auricular region	UBERON:0006631	70.88	gold quality
body of pancreas	UBERON:0001150	70.65	gold quality
heart	UBERON:0000948	70.64	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.23	gold quality
adult mammalian kidney	UBERON:0000082	69.96	gold quality
myometrium	UBERON:0001296	69.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.95	gold quality
popliteal artery	UBERON:0002250	69.87	gold quality
body of stomach	UBERON:0001161	69.84	gold quality
tibial artery	UBERON:0007610	69.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.