MIR6807

Summary

MIR6807 (microRNA 6807, HGNC:50191) is a microRNA gene on chromosome 19q13.43.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465976 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50191
Approved symbol	MIR6807
Name	microRNA 6807
Location	19q13.43
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6807
Ensembl gene	ENSG00000275924
Ensembl biotype	miRNA
Entrez	102465976
RNAcentral	URS000075B296 — ncRNA, 92 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621968

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621968 — 1 exons

Exon	Start	End
ENSE00003751255	58550285	58550376

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 82.26.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	82.26	gold quality
granulocyte	CL:0000094	82.24	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.05	gold quality
vermiform appendix	UBERON:0001154	78.06	gold quality
blood	UBERON:0000178	77.78	gold quality
lymph node	UBERON:0000029	77.33	gold quality
monocyte	CL:0000576	76.56	gold quality
mucosa of transverse colon	UBERON:0004991	76.32	gold quality
adrenal tissue	UBERON:0018303	76.26	gold quality
islet of Langerhans	UBERON:0000006	75.50	gold quality
muscle of leg	UBERON:0001383	75.31	gold quality
gastrocnemius	UBERON:0001388	74.98	gold quality
right lobe of liver	UBERON:0001114	74.81	gold quality
liver	UBERON:0002107	74.73	gold quality
left adrenal gland cortex	UBERON:0035825	74.55	gold quality
prefrontal cortex	UBERON:0000451	74.47	gold quality
stomach	UBERON:0000945	74.35	gold quality
body of stomach	UBERON:0001161	74.22	gold quality
placenta	UBERON:0001987	74.16	gold quality
left adrenal gland	UBERON:0001234	73.42	gold quality
left uterine tube	UBERON:0001303	73.27	gold quality
adrenal gland	UBERON:0002369	72.97	gold quality
heart left ventricle	UBERON:0002084	72.75	gold quality
kidney	UBERON:0002113	72.56	gold quality
adult mammalian kidney	UBERON:0000082	72.53	gold quality
lower esophagus mucosa	UBERON:0035834	72.43	gold quality
left ovary	UBERON:0002119	72.31	gold quality
heart	UBERON:0000948	72.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.18	gold quality
ectocervix	UBERON:0012249	72.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Aberrant expression of DACH1 was associated with the clinical survival of glioma patients. Furthermore, overexpression of DACH1 rescued the promotive effects of miR-6807-3p in glioma. Based on these findings, a novel miR-6807-3p may act as a glioma enhancer by targeting DACH1. (PMID:30527681)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.