MIR6808

Summary

MIR6808 (microRNA 6808, HGNC:50046) is a microRNA gene on chromosome 1p36.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466740 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50046
Approved symbol	MIR6808
Name	microRNA 6808
Location	1p36.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6808
Ensembl gene	ENSG00000284372
Ensembl biotype	miRNA
Entrez	102466740
RNAcentral	URS000075F035 — ncRNA, 59 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616525

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616525 — 1 exons

Exon	Start	End
ENSE00003739900	1339650	1339708

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 86.39.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	86.39	gold quality
bone marrow	UBERON:0002371	84.94	gold quality
putamen	UBERON:0001874	72.88	gold quality
gastrocnemius	UBERON:0001388	71.52	gold quality
esophagus mucosa	UBERON:0002469	67.05	gold quality
hypothalamus	UBERON:0001898	66.41	gold quality
ascending aorta	UBERON:0001496	66.31	gold quality
cerebellar hemisphere	UBERON:0002245	65.71	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.24	gold quality
tibial artery	UBERON:0007610	65.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.18	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.61	gold quality
upper lobe of left lung	UBERON:0008952	61.59	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	55.68	gold quality
spleen	UBERON:0002106	54.91	gold quality
thyroid gland	UBERON:0002046	52.12	gold quality
skin of leg	UBERON:0001511	51.12	gold quality
left lobe of thyroid gland	UBERON:0001120	49.70	gold quality
tibial nerve	UBERON:0001323	49.29	gold quality
pituitary gland	UBERON:0000007	44.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.