MIR6809

Summary

MIR6809 (microRNA 6809, HGNC:49926) is a microRNA gene on chromosome 2q35.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465485 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49926
Approved symbol	MIR6809
Name	microRNA 6809
Location	2q35
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6809
Ensembl gene	ENSG00000275458
Ensembl biotype	miRNA
Entrez	102465485
RNAcentral	URS000075C238 — miRNA, 116 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612189

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612189 — 1 exons

Exon	Start	End
ENSE00003746042	217900513	217900628

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 86.40.

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	86.40	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.34	gold quality
adrenal tissue	UBERON:0018303	83.23	gold quality
liver	UBERON:0002107	82.82	gold quality
blood	UBERON:0000178	77.67	gold quality
corpus callosum	UBERON:0002336	76.45	gold quality
adult mammalian kidney	UBERON:0000082	76.18	gold quality
right lobe of liver	UBERON:0001114	75.86	gold quality
cortex of kidney	UBERON:0001225	75.73	gold quality
kidney	UBERON:0002113	75.73	gold quality
skeletal muscle tissue	UBERON:0001134	75.38	gold quality
monocyte	CL:0000576	74.90	gold quality
muscle of leg	UBERON:0001383	74.26	gold quality
stomach	UBERON:0000945	74.24	gold quality
islet of Langerhans	UBERON:0000006	73.77	gold quality
gastrocnemius	UBERON:0001388	73.46	gold quality
descending thoracic aorta	UBERON:0002345	73.37	gold quality
popliteal artery	UBERON:0002250	73.22	gold quality
tibial artery	UBERON:0007610	73.08	gold quality
ascending aorta	UBERON:0001496	73.03	gold quality
thoracic aorta	UBERON:0001515	72.85	gold quality
body of pancreas	UBERON:0001150	72.50	gold quality
calcaneal tendon	UBERON:0003701	72.46	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.07	gold quality
metanephros cortex	UBERON:0010533	71.69	gold quality
lower esophagus	UBERON:0013473	71.34	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.32	gold quality
myometrium	UBERON:0001296	70.98	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.79	gold quality
placenta	UBERON:0001987	70.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MiR-6809-5p directly targets flotillin 1 (FLOT1) in hepatoma cells. (PMID:30668319)
• Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis. (PMID:38422911)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.