MIR6810

Summary

MIR6810 (microRNA 6810, HGNC:49987) is a microRNA gene on chromosome 2q35.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466197 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49987
Approved symbol	MIR6810
Name	microRNA 6810
Location	2q35
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6810
Ensembl gene	ENSG00000278524
Ensembl biotype	miRNA
Entrez	102466197
RNAcentral	URS000075B5D2 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622701

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622701 — 1 exons

Exon	Start	End
ENSE00003733820	218341911	218341980

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 83.91.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	83.91	gold quality
adrenal tissue	UBERON:0018303	77.12	gold quality
monocyte	CL:0000576	75.52	gold quality
placenta	UBERON:0001987	73.84	gold quality
gastrocnemius	UBERON:0001388	73.29	gold quality
blood	UBERON:0000178	73.26	gold quality
amygdala	UBERON:0001876	72.02	gold quality
hypothalamus	UBERON:0001898	71.37	gold quality
stomach	UBERON:0000945	71.06	gold quality
right lobe of liver	UBERON:0001114	70.81	gold quality
body of stomach	UBERON:0001161	70.74	gold quality
tonsil	UBERON:0002372	70.59	gold quality
right atrium auricular region	UBERON:0006631	70.22	gold quality
endometrium	UBERON:0001295	70.14	gold quality
liver	UBERON:0002107	70.03	gold quality
fundus of stomach	UBERON:0001160	69.85	gold quality
tibial artery	UBERON:0007610	69.75	gold quality
kidney	UBERON:0002113	69.72	gold quality
rectum	UBERON:0001052	69.41	gold quality
heart	UBERON:0000948	69.38	gold quality
adult mammalian kidney	UBERON:0000082	69.12	gold quality
adrenal gland	UBERON:0002369	69.04	gold quality
right lung	UBERON:0002167	68.58	gold quality
heart left ventricle	UBERON:0002084	68.35	gold quality
ascending aorta	UBERON:0001496	68.09	gold quality
fallopian tube	UBERON:0003889	67.96	gold quality
urinary bladder	UBERON:0001255	67.84	gold quality
body of pancreas	UBERON:0001150	67.78	gold quality
left adrenal gland	UBERON:0001234	67.34	gold quality
right frontal lobe	UBERON:0002810	66.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.