MIR6811

Summary

MIR6811 (microRNA 6811, HGNC:49944) is a microRNA gene on chromosome 2q37.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465486 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49944
Approved symbol	MIR6811
Name	microRNA 6811
Location	2q37.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6811
Ensembl gene	ENSG00000277842
Ensembl biotype	miRNA
Entrez	102465486
RNAcentral	URS000075E1E5 — miRNA, 58 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620409

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620409 — 1 exons

Exon	Start	End
ENSE00003746305	237510931	237510988

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 76.98.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	76.98	gold quality
heart left ventricle	UBERON:0002084	71.97	gold quality
right frontal lobe	UBERON:0002810	69.99	gold quality
heart	UBERON:0000948	69.40	gold quality
esophagus mucosa	UBERON:0002469	68.82	gold quality
transverse colon	UBERON:0001157	68.52	gold quality
right atrium auricular region	UBERON:0006631	66.92	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.80	gold quality
thoracic mammary gland	UBERON:0005200	66.64	gold quality
skin of abdomen	UBERON:0001416	64.96	gold quality
upper lobe of left lung	UBERON:0008952	64.91	gold quality
lung	UBERON:0002048	64.78	gold quality
prostate gland	UBERON:0002367	64.26	gold quality
fundus of stomach	UBERON:0001160	64.25	gold quality
left lobe of thyroid gland	UBERON:0001120	64.21	gold quality
nucleus accumbens	UBERON:0001882	63.96	gold quality
stomach	UBERON:0000945	57.58	gold quality
left testis	UBERON:0004533	47.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiRNA-423 rs6505162 and miRNA-6811 rs2292879 SNP associated with lung cancer in Hainan, China. (PMID:37694278)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.