MIR6812

Summary

MIR6812 (microRNA 6812, HGNC:50116) is a microRNA gene on chromosome 20q13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465487 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50116
Approved symbol	MIR6812
Name	microRNA 6812
Location	20q13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6812
Ensembl gene	ENSG00000273555
Ensembl biotype	miRNA
Entrez	102465487
RNAcentral	URS000075B2E6 — ncRNA, 64 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619733

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619733 — 1 exons

Exon	Start	End
ENSE00003739114	45425510	45425573

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 88.90.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	88.90	gold quality
granulocyte	CL:0000094	86.48	gold quality
vermiform appendix	UBERON:0001154	84.41	gold quality
duodenum	UBERON:0002114	84.35	gold quality
lymph node	UBERON:0000029	84.01	gold quality
bone marrow	UBERON:0002371	81.06	gold quality
apex of heart	UBERON:0002098	80.74	gold quality
placenta	UBERON:0001987	78.67	gold quality
prefrontal cortex	UBERON:0000451	77.23	gold quality
monocyte	CL:0000576	76.88	gold quality
blood	UBERON:0000178	76.87	gold quality
muscle of leg	UBERON:0001383	76.23	gold quality
fundus of stomach	UBERON:0001160	75.46	gold quality
body of stomach	UBERON:0001161	74.94	gold quality
stomach	UBERON:0000945	74.86	gold quality
heart left ventricle	UBERON:0002084	74.82	gold quality
gastrocnemius	UBERON:0001388	74.55	gold quality
transverse colon	UBERON:0001157	74.10	gold quality
heart	UBERON:0000948	73.87	gold quality
colon	UBERON:0001155	73.76	gold quality
intestine	UBERON:0000160	73.73	gold quality
small intestine Peyer’s patch	UBERON:0003454	73.41	gold quality
muscle layer of sigmoid colon	UBERON:0035805	73.33	gold quality
endometrium	UBERON:0001295	73.20	gold quality
right atrium auricular region	UBERON:0006631	73.16	gold quality
right coronary artery	UBERON:0001625	73.09	gold quality
spleen	UBERON:0002106	72.82	gold quality
right adrenal gland cortex	UBERON:0035827	72.12	gold quality
right adrenal gland	UBERON:0001233	71.94	gold quality
left adrenal gland cortex	UBERON:0035825	71.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• circMTND5 Participates in Renal Mitochondrial Injury and Fibrosis by Sponging MIR6812 in Lupus Nephritis. (PMID:36267809)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.