MIR6813

Summary

MIR6813 (microRNA 6813, HGNC:50017) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466741 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50017
Approved symbol	MIR6813
Name	microRNA 6813
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6813
Ensembl gene	ENSG00000274034
Ensembl biotype	miRNA
Entrez	102466741
RNAcentral	URS0000759B25 — ncRNA, 56 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621638

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621638 — 1 exons

Exon	Start	End
ENSE00003747605	64076955	64077010

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 88.29.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	88.29	gold quality
blood	UBERON:0000178	87.42	gold quality
vermiform appendix	UBERON:0001154	85.99	gold quality
bone marrow	UBERON:0002371	83.27	gold quality
lymph node	UBERON:0000029	81.32	gold quality
tonsil	UBERON:0002372	81.27	gold quality
monocyte	CL:0000576	78.73	gold quality
spleen	UBERON:0002106	78.20	gold quality
muscle of leg	UBERON:0001383	77.77	gold quality
prefrontal cortex	UBERON:0000451	76.11	gold quality
gastrocnemius	UBERON:0001388	75.82	gold quality
myometrium	UBERON:0001296	73.65	gold quality
left coronary artery	UBERON:0001626	72.33	gold quality
small intestine	UBERON:0002108	72.18	gold quality
stomach	UBERON:0000945	72.07	gold quality
body of stomach	UBERON:0001161	71.95	gold quality
body of pancreas	UBERON:0001150	71.89	gold quality
right atrium auricular region	UBERON:0006631	71.66	gold quality
heart left ventricle	UBERON:0002084	71.59	gold quality
small intestine Peyer’s patch	UBERON:0003454	71.55	gold quality
endocervix	UBERON:0000458	71.36	gold quality
substantia nigra	UBERON:0002038	71.32	gold quality
tibial artery	UBERON:0007610	71.29	gold quality
adult mammalian kidney	UBERON:0000082	70.81	gold quality
right adrenal gland	UBERON:0001233	70.70	gold quality
amygdala	UBERON:0001876	70.70	gold quality
urinary bladder	UBERON:0001255	70.62	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.36	gold quality
endometrium	UBERON:0001295	70.06	gold quality
lung	UBERON:0002048	69.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.